Targeted Protein Degrader-Chemistry

Services & Solutions

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Platform

Small Molecule CRDMO

Oligonucleotide and Peptide CRDMO

C"R"DMO

CR"DM"O

Targeted Protein Degrader

Carbohydrate Chemistry

Nucleoside/tide

Macrocyclic Chemistry

Boron Chemistry

Steroids Chemistry

Nanomedicine

Computer-aided Drug Design

Library

Compound Management

Reaction Condition Screening

Fluorescent Bio-probe and Labeling

Quantum Mechanics

Late Stage Functionalization

Catalysis Screening

Chemical Synthesis Service

Discovery Process Chemistry

Bio-transformation

Impurity Proofing

Isotopic Labeling Chemistry

Crystallization Platform

Analysis & Purification

Fluorine Chemistry

Targeted Protein Degrader

Flow Chemistry Service

Electrochemistry

Photoredox Chemistry

Synthesis, Analysis, Purification and DMPK

Over 1,000 chemists with extensive experience in synthesizing linkers, E3 ligase ligands, and target protein ligands since 2016

Engaged with >150 clients/collaborations

Synthesized >158,000 compounds and >1,000 diverse linkers

Expertise in synthesizing versatile linkers with 100+ readily available

Novel linker synthesis with high productivity, quality, speed, and reliability

Deep experience in CRBN/VHL/IAP/MDM2 and other novel E3 ligase ligand synthesis, with >30 CRBN/VHL ligands readily available

>60 series of target protein ligands pre-coupled with various linkers

More than 200 methods of prep-HPLC and chiral-SFC for analysis and purification

Comprehensive in-vitro/in-vivo testing by the WuXi DMPK team

Innovative online dilution system designed for Targeted Protein Degraders

Native-MS analysis for ternary complex confirmation

Proteomics studies to identify off-target effects

Well-established Modular System

A modular platform: More efficient Targeted Protein Degrader synthesis

Customized Targeted Protein Degrader: From mg to kg scale

Linkers: Most frequently used linkers, e.g. PEG, alkyl, ”clickable”, and rigid linkers

In-stock compounds: More than 200 in-stock linkers or E3 ligase ligands based on literatures

E3 ligase ligands: More than 150 common ligands are readily available, e.g. VHL, CRBN, cIAP

Traditional FFS

From mg to hundreds of kg

> 158,000 compounds synthesized

> 90% on-time delivery

Library

> 100 libraries finished

1~5 step parallel synthesis

2~4 weeks of turn-around time