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Small Molecule
Small Molecule
WuXi TIDES(Oligonucleotide and Peptide CRDMO Service)
C"R"DMO
C"R"DMO
CR"DM'O
Nanomedicine
Carbohydrate Chemistry
Nucleoside/tide
Macrocyclic Chemistry
Boron Chemistry
Steroids Chemistry
Nanomedicine
Computer-aided Drug Design
Library
Compound Management
Reaction Condition Screening
Fluorescent Bio-probe and Labeling
Quantum Mechanics
Late Stage Functionalization
Catalysis Screening
Custom Synthesis
Discovery Process Chemistry
Bio-transformation
Impurity Proofing
Isotopic Labeling Chemistry
Crystallization Platform
Analysis & Purification
Fluorine Chemistry
PROTAC <sup>®</sup> Platform
Flow Chemistry Service
Electrochemistry
Photoredox Chemistry
mg~gram scale, >95% purity syntheses of lipids and polymers
Formulation of lipid nanoparticles and polymeric nanoparticles.
Target delivery of small molecule and oligo drugs to specific organs.
Integrate services.
Lipid Synthesis
Polymer Synthesis
Lipid Nanoparticle
Polymeric Nanoparticle
Inorganic Nanoparticle
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Target Delivery
Integrate Service
Broad synthetic scale from milligram to gram
Variety of lipid products, including Ionizable lipids, neutral lipids, hybrid sterol and phospholipids
>95% purity
Some lipids and many intermediates are in stock
Broad synthetic scale from milligram to gram
Products are confirmed by MALDI-TOF, NMR, GPC and LCMS
Synthesis
Purification
Identification
As an example,WuXi’s Nanomedicine platform provide microfluid formulation to deliver encapsulated drugs(including small molecules or Oligos) in Liposome or Lipid Nanoparticles with appropriate size.
Part A
Lipid, 45%
Helper lipid, ~8%
PEG-DMG, ~2%
Cholesterol, ~45%
In ethanol
Part B
RNA in water
(N/P = 4~4.5)
Condition Screening
Microfluid
Dialysis
DLS
DLS
Extruder
In vitro (300~500μL/run)
In vivo (20-500mL)
Polymeric nanoparticles were well used in drug delivery of small molecules and oligo drugs.
Drug
Polymer
Stabilizer
Helper
Solvent
Sonication
Evaporation
Microfluid
Emulsion
Lyophilization
Inorganic nanoparticles includes Au, Ag, FexOy and silica were well used in drug delivery of small molecules and oligos. Hybrid nanoparticles including inorganic materials as cores, were adopted to deliver drugs for in vitro/in vivo research.
Syntheses of known/ novel lipids/polymers;
Syntheses of lipid or polymer helpers;
Formulation condition screening and optimization;
For in vitro/in vivo research;
Idea and solution of specific delivery.
WuXi AppTec’s Nanomedicine Platform can design specific nanocarriers to deliver drugs to organs to support clients’ research and match clients’ specific needs.
Conjugation of specific components to lipids, polymers or even nanoparticles, or additives are adopted in Target Delivery to specific organs such as CNS, Lung, Liver, Kidney, Spleen and Colon.
Syntheses of known/ novel lipids/polymers;
Syntheses of lipid or polymer helpers;
Formulation condition screening and optimization;
For in vitro/in vivo research;
Idea and solution of specific delivery.
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Our Nanomedicine Platform provides One-Stop service including:
Syntheses of known/ novel lipids/polymers;
Syntheses of lipid or polymer helpers;
Formulation condition screening and optimization;
For in vitro/in vivo research;
Idea and solution of specific delivery.
Nanomedicine Synthesis
Polymer Synthesis
Lipid Nanoparticle
Polymeric Nanoparticle
Inorganic Nanoparticles
Target Delivery
One-stop Service