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Platform

Small Molecule CRDMO

Small Molecule CRDMO

Oligonucleotide and Peptide CRDMO

C"R"DMO

C"R"DMO

CR"DM"O

Library

Carbohydrate Chemistry

Nucleoside/tide

Macrocyclic Chemistry

Boron Chemistry

Steroids Chemistry

Nanomedicine

Computer-aided Drug Design

Library

Compound Management

Reaction Condition Screening

Fluorescent Bio-probe and Labeling

Quantum Mechanics

Late Stage Functionalization

Catalysis Screening

Chemical Synthesis Service

Discovery Process Chemistry

Bio-transformation

Impurity Proofing

Isotopic Labeling Chemistry

Crystallization Platform

Analysis & Purification

Fluorine Chemistry

Targeted Protein Degrader

Flow Chemistry Service

Electrochemistry

Photoredox Chemistry

WuXi Library Overview

20 Years of experience in high-quality services on combinatorial chemistry and small molecule library design and synthesis, with more than 3 million compounds delivered so far, providing fast and comprehensive research support in drug discovery and agro / crop science projects worldwide

Offering world class service in design and synthesis of all library types at competitive price, such as parallel medicinal chemistry library, library enrichment project, focused / targeted library and virtual library

Streamlined process with high efficiency to accelerate library production. As quick as 7 calendar days from project initiation to whole library delivery

Exceeding client’s expectation on product quality by strict and multi-level quality control procedures. Each compound is checked by LCMS and/or 1H NMR before delivery

Heavy investment to build up in house reaction condition screening platform to speed up problem solving and increase success rate

Applying cutting-edge chemistry methodologies such as photoredox chemistry to library synthesis. Finalized several photoredox libraries with up to 100% success rate

Over 50,000 reagents and 15,000 unique scaffolds/building blocks in stock to enhance library design with novelty and diversity, and expedite production with materials ready for bench chemists within 24 h

Design

Library Design 1
Library Design 1

Synthesis

Library Synthesis 1
Library Synthesis 2

Delivery

Library Delivery 1
Library Delivery 2

WuXi Virtual Library (WuXi GalaXi)

WuXi GalaXi

Phase1

BB docking

50M virtual compounds

>90K BBs

> 40 reactions

>120 protocols

~75% success rate

Deliver in 4-6 weeks

Phase2

WuXi unique Template

9B virtual compounds

WuXi unique template & building blocks

More reaction types

More protocols

Deliver in 6-8 weeks

Phase3

Drug Like Core

8.2B Virtual compounds

Design Drug Like core

More Building Blocks

Docking with protein

~75% Success rate

Deliver in 6-8 weeks

Data Analysis

Profiles

Library Data 1
Library Data 2
Library Data 3
Library Data 4
Library Data 5
Library Data 6

Diversity

Bemis-Murcko framework

Cover 10,353 frameworks

Size range  for each framework:  1 - 1,362

Average size for each framework: 11.3

Most frequently (>0.2%) occurring 79 frameworks, only account for 24% of whole DB

Library Sample 116,540 compounds

Sample 116,540 compounds