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Small Molecule

Small Molecule

WuXi TIDES(Oligonucleotide and Peptide CRDMO Service)

C"R"DMO

C"R"DMO

CR"DM'O

Library

Carbohydrate Chemistry

Nucleoside/tide

Macrocyclic Chemistry

Boron Chemistry

Steroids Chemistry

Nanomedicine

Computer-aided Drug Design

Library

Compound Management

Reaction Condition Screening

Fluorescent Bio-probe and Labeling

Quantum Mechanics

Late Stage Functionalization

Catalysis Screening

Custom Synthesis

Discovery Process Chemistry

Bio-transformation

Impurity Proofing

Isotopic Labeling Chemistry

Crystallization Platform

Analysis & Purification

Fluorine Chemistry

PROTAC <sup>®</sup> Platform

Flow Chemistry Service

Electrochemistry

Photoredox Chemistry

Overview

20 Years of experience in high-quality services on combinatorial chemistry and small molecule library design and synthesis, with more than 3 million compounds delivered so far, providing fast and comprehensive research support in drug discovery and agro / crop science projects worldwide

Offering world class service in design and synthesis of all library types at competitive price, such as parallel medicinal chemistry library, library enrichment project, focused / targeted library and virtual library

Streamlined process with high efficiency to accelerate library production. As quick as 7 calendar days from project initiation to whole library delivery

Exceeding client’s expectation on product quality by strict and multi-level quality control procedures. Each compound is checked by LCMS and/or 1H NMR before delivery

Heavy investment to build up in house reaction condition screening platform to speed up problem solving and increase success rate

Applying cutting-edge chemistry methodologies such as photoredox chemistry to library synthesis. Finalized several photoredox libraries with up to 100% success rate

Over 25,000 reagents and 8,000 unique scaffolds / building blocks in stock to facilitate library design with novelty and diversity, and expedite library production with material readiness for bench chemists within 24 hours

Design

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Synthesis

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Delivery

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WuXi Virtual Library

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Phase1

BB docking

50M virtual compounds

>90K BBs

> 38 reactions

>128 protocols

~75% success rate

Deliver in 4-6 weeks

Phase2

WuXi unique Template

1.7B virtual compounds

WuXi unique template

WuXi unique BBs

More reaction types

More protocol

Deliver in 6-8 weeks

Phase3

Drug Like Core

0.6 B More coming soon

Design Drug Like core

More BBs

Docking with protein

(coming soon)

Data Analysis

Profiles

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Diversity

Bemis-Murcko framework

Cover 10,353 frameworks

Size range for each framework: 1 - 1,362

Average size for each framework: 11.3

Most frequently (>0.2%) occurring 79 frameworks, only account for 24% of whole DB

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Sample 116,540 compounds