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Small Molecule
Small Molecule
WuXi TIDES(Oligonucleotide and Peptide CRDMO Service)
C"R"DMO
C"R"DMO
CR"DM'O
Late Stage Functionalization
Carbohydrate Chemistry
Nucleoside/tide
Macrocyclic Chemistry
Boron Chemistry
Steroids Chemistry
Nanomedicine
Computer-aided Drug Design
Library
Compound Management
Reaction Condition Screening
Fluorescent Bio-probe and Labeling
Quantum Mechanics
Late Stage Functionalization
Catalysis Screening
Custom Synthesis
Discovery Process Chemistry
Bio-transformation
Impurity Proofing
Isotopic Labeling Chemistry
Crystallization Platform
Analysis & Purification
Fluorine Chemistry
PROTAC <sup>®</sup> Platform
Flow Chemistry Service
Electrochemistry
Photoredox Chemistry
Advance Intermediates Identification
High Throughput Functionalization
Rapid Analysis & Purification
Precise Structure Assignment
Late-stage functionalization (LSF) utilizes highly selective reactions to introduce substituents to advance intermediates under mild conditions to diversify substitutions in lead structures for acceleration of chemistry related discoveries.1 LSF is also used to prepare specific targets that may not be easily accessible by conventional approaches. We provide unique Integrated LSF Services to our customers, incorporating
Quantum Mechanics (QM) analyses of advanced intermediates available2 to access their reactivity and regio-selectivity for the CH activations reaction types of interest, from CH-alkylation to fluorination to halogenation to oxidation to trifluoromethylation, etc.;
Synthesis of the key intermediates;
High Throughput Processing in our Catalysis or PhotoRedox Laboratories;
Rapid parallel LC-MS analyses and purification of reaction samples;
QM and DP4-AI assisted structure assignments for complex structures. 3
1 Moir, M. et al, Expert Opin Drug Discov., 2019, 14, 1137.
3 Goodman, J.M. et al, Chem. Sci. 2020,11, 4351.