Choose language
< Return to main menu
b13pcban.jpg 15.jpg

Late Stage Functionalization

Services & Solutions

Services & Solutions

News & Events


Small Molecule

Small Molecule

WuXi TIDES(Oligonucleotide and Peptide CRDMO Service)




Late Stage Functionalization

Carbohydrate Chemistry


Macrocyclic Chemistry

Boron Chemistry

Steroids Chemistry


Computer-aided Drug Design


Compound Management

Reaction Condition Screening

Fluorescent Bio-probe and Labeling

Quantum Mechanics

Late Stage Functionalization

Catalysis Screening

Custom Synthesis

Discovery Process Chemistry


Impurity Proofing

Isotopic Labeling Chemistry

Crystallization Platform

Analysis & Purification

Fluorine Chemistry

PROTAC <sup>®</sup> Platform

Flow Chemistry Service


Photoredox Chemistry


Advance Intermediates Identification

High Throughput Functionalization

Rapid Analysis & Purification

Precise Structure Assignment

Late-stage functionalization (LSF) utilizes highly selective reactions to introduce substituents to advance intermediates under mild conditions to diversify substitutions in lead structures for acceleration of chemistry related discoveries.1 LSF is also used to prepare specific targets that may not be easily accessible by conventional approaches. We provide unique Integrated LSF Services to our customers, incorporating

Quantum Mechanics (QM)  analyses of advanced intermediates available2 to access their reactivity and regio-selectivity for the CH activations reaction types of interest, from CH-alkylation to fluorination to halogenation to oxidation to trifluoromethylation, etc.;

Synthesis of the key intermediates;

High Throughput Processing in our Catalysis or PhotoRedox Laboratories;

Rapid parallel LC-MS analyses and purification of reaction samples;

QM and DP4-AI assisted structure assignments for complex structures. 3

1 Moir, M. et al, Expert Opin Drug Discov., 2019, 14, 1137.

2 QM analyses

3 Goodman, J.M. et al, Chem. Sci. 2020,11, 4351.