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Oligonucleotide

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Oligonucleotide

Small Molecule

Oligonucleotide

Peptide

Discovery Oligonucleotide:

a one-stop shop to create ‘monomer → oligo → conjugate’

Oligonucleotide CMC Platform

from customized monomers, linkers, conjugates, APIs to drug products

Broad Coverage

ASO, siRNA, Aptamer, microRNA, PMO etc

GalNAc conjugated SiRNA

PMO based conjugates

Oligo-toxin / Oligo-antibody

Oligonucleotide conjugates including

GalNAc conjugated SiRNA

PMO based conjugates

Oligo-toxin / Oligo-antibody

Full suite of analytical testing

GalNAc conjugated SiRNA

PMO based conjugates

Oligo-toxin / Oligo-antibody

Chemistry Powerhouse

Solid phase + liquid phase synthesis

GalNAc conjugated SiRNA

PMO based conjugates

Oligo-toxin / Oligo-antibody

Conjugation chemistry

GalNAc conjugated SiRNA

PMO based conjugates

Oligo-toxin / Oligo-antibody

Linker and ligand synthesis

GalNAc conjugated SiRNA

PMO based conjugates

Oligo-toxin / Oligo-antibody

Custom phosphoramidite synthesis

GalNAc conjugated SiRNA

PMO based conjugates

Oligo-toxin / Oligo-antibody

GalNAc synthesis

GalNAc conjugated SiRNA

PMO based conjugates

Oligo-toxin / Oligo-antibody

Oligo Production Lines from Lab Scale to Production Scale

OligoPilot™100

GalNAc conjugated SiRNA

PMO based conjugates

Oligo-toxin / Oligo-antibody

OligoPilot™400

GalNAc conjugated SiRNA

PMO based conjugates

Oligo-toxin / Oligo-antibody

OligoProcess™

GalNAc conjugated SiRNA

PMO based conjugates

Oligo-toxin / Oligo-antibody

PMO lines

GalNAc conjugated SiRNA

PMO based conjugates

Oligo-toxin / Oligo-antibody

Injectable Formulation Development and Manufacturing Platform

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Dosage Forms

Injection, solution

Injection, emulsion

Injection, sterile powder (Lyophilized)

Injection, liposome

Ophthalmic solution

Nasal spray solution

Filling Capability

Vial, prefilled syringe, cartridge

Single-use mixing-filtration-filling system with sterile container closure system

Expansion Plan

4 more injectable lines including high potency injectable lines are ready by 2022 to support more clinical and commercial projects

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